The ministry did not give the exact number of casualties or their identities, but said that the bus was carrying passengers who were trying to flee the Israeli bombardment.
The zionist occupation regime has been carrying out a relentless aerial campaign against Gaza since Oct. 7, after Hamas launched a surprise operation.
The zionist military has urged residents of northern Gaza to evacuate to the south, warning of imminent attacks on the densely populated area.
More than a million people have been internally displaced by the violence, according to the United Nations.
The Palestinian health ministry said that at least 8,000 people, half of them children, have been killed by israeli airstrikes since the start of the conflict.
It also said that more than 20,000 people have been injured and thousands of homes and infrastructure have been destroyed. (ILKHA)
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