The accident involved a bus, a car, a truck, and a snow plough vehicle, according to initial reports.
Ambulances, Firefighters, police gendarmerie officers, and units from local directorates of the Directorate General of Highways (KGM) and Disaster and Emergency Management Authority (AFAD) flocked to the scene to help those who were injured in the pileup.
Officials said that one driver died and four people were injured in the accident.
Following the accident, the highway connecting Istanbul and Ankara was closed to traffic. (ILKHA)