The bus was heading from the city of Huanuco to the Peruvian capital, Lima, when it crashed over a barrier and plunged onto a rocky cliff overlooking the river in Huarochiri Province in the central coastal region of Peru at 2:30 a.m. (07:30 GMT), according to local media reports.
The injured were admitted to a local hospital, the local police said.
Authorities have launched an investigation into the incident. (ILKHA)