The accident took place late Tuesday, according to provincial authorities.
Ambulances rushed to the scene to carry bodies and the injured to the Sohag Public Hospital, local officials said.
Deadly traffic accidents claim thousands of lives every year in Egypt due to speeding, bad roads or poor enforcement of traffic laws.
In July, a passenger bus crashed into a parked trailer truck on a highway in the southern province of Minya, leaving 23 dead and 30 more injured. (ILKHA)